Fig. 2: Reaction development and substrate scope.
From: Ligand-modulated nickel-catalyzed regioselective silylalkylation of alkenes
a Reaction discovery; b Substrate scope. aReaction conditions: NiBr2·DME (5 mol%), L (7 mol%), CuI (15 mol%), 1a (0.4 mmol, 1.0 equiv), 2a (0.8 mmol, 2.0 equiv), 3a (0.6 mmol, 1.5 equiv), LiOMe (0.8 mmol, 2.0 equiv), NMP (2 mL), 30 °C, 36 h; b50 °C; c40 °C; d5 °C; e10 °C; fAddition of KI (0.5 equiv); gReaction conditions: NiBr2·DME (5 mol%), L9 (7 mol%), CuI (15 mol%), KI (0.5 equiv), 1 (0.4 mmol, 1.0 equiv), 2a (0.6 mmol, 1.5 equiv), 3 (0.8 mmol, 2.0 equiv), LiOMe (0.8 mmol, 2.0 equiv), NMP (2 mL), 5 °C, 36 h; hL8 instead of L9, KI (0.2 equiv); i30 °C, 36 h; jIsolated yield of the corresponding alcohol after oxidation.
