Fig. 8: Complex activation pathways of βarr1 induced by different binding partners.
From: Distinct activation mechanisms of β-arrestin-1 revealed by 19F NMR spectroscopy
a A schematic illustration showing the binding of receptor tail, receptor TM core, PIP2 and the lipid bilayer to different structural regions of βarr1 (orange arrows), and transduction of conformational changes towards the gate loop, a central hub undergoing substantial rearrangements during activation. b An illustrative diagram showing the modulation of βarr1 conformational energy landscape by different binding events. c Schematic illustrations showing the hypothesized differences of βarr1 activation by class B and class A receptors. The color changes in different regions of βarr1 (the N-domain, the C-domain and the central crest) represent their individual binding and structural activation events.
