Fig. 3: Differentially accessible transposable elements in FAD hpNPCs. | Nature Communications

Fig. 3: Differentially accessible transposable elements in FAD hpNPCs.

From: JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer’s disease

Fig. 3: Differentially accessible transposable elements in FAD hpNPCs.The alternative text for this image may have been generated using AI.

a Differentially accessible (DA) regions in the FAD hpNPCs compared to CTRL hpNPCs. FAD Up = significantly more accessible in FAD relative to CTRLs; FAD Down = significantly less accessible in FAD relative to CTRLs. b DA regions located near a differentially expressed gene. c DA regions near differentially expressed genes are predominantly enhancers (>1 kb from the transcription start site [TSS]). d MEME-ChIP analysis of 3382 DA regions uncovered the JUN binding motif as enriched. e Heatmap showing the top 50 TE copies identified as significantly more accessible in FAD than CTRL hpNPCs. One of the FAD samples was removed from the analysis and heatmap, as preliminary PCA revealed it behaved as an outlier, suggesting a technical issue with the sample. f, g. Family distribution of the aberrantly active TEs in FAD progenitors. h The aberrantly active LTRs are enriched for the JUN motif.

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