Table 1 Somatic variants are almost never shared in paired synchronous bilateral Wilms tumor

From: Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q

SJWLM

Blood germline

Somatic variants right kidney tumor

Somatic variants left kidney tumor

Shared both kidney tumors

Adjacent normal kidney

Blood H19/ICR1 methylation > 2 SD from normal

066770

REST p.H379P

DHX36, EIF1AX, HCG22, RPS10P7

ALPK2, BCORL1, GUSBP4, H3F3A, IZKF4, PLCH2, PPFIA4, RBBP4, STAT4, REST, IL2RB, GRLF1, LRRC16B

11p15.5 LOH

N/A

No

066771

None

VCX3A

LOC26102, PPCDC, R3HDM1

11p15.5 LOI

N/A

Yes

066773

TRIM28 p.Q318*, BRCA1 p.Q687P

CDK13, TAS2R60

ITM2C, LOC100133161, LOC339822

11p15.5 ROI

N/A

No

066776

WT1 p.Q253*

AIM1L, CAMK2B, CTNNB1 p.S45F, DHX30, EBF4, NLRC5, OR4C11, PPL

CTNNB1 p.S45del, DBH, DDX60, NANOS1, NELL1, TUBB1, ZFHX4, ATE1, RERE

11p15.5 LOH

11p15.5 ROI R + L

No

066777

TRIM28 p.R795C

NCRNA00245, TCHH

C14orf73, REG3A, SLC12A1

11p15.5 ROI

N/A

No

066778

None

GPR97, IL31RA, RAD17

CYC1, EMX2OS, KIAA0664, KIF6, MAML3, NES, NR0B1, PKHD1L1, SRRM5, TBX4, TRMT61B, ZNF833P

11p15.5 LOI

11p15.5 ROI L

No

066779

BLM p.K323R

ATP6AP2, C22orf34, DACH1, DROSHA, MAP7D3, PITPNM2, SIX1

ABCC12, DGCR8, LOC401177, MARCH7, SLC17A7, SIDT2

11p15.5 LOI

11p15.5 LOI L

No

066780

WT1 p.E401fs

ARHGAP9, C1orf106, CHST3, CTNNB1, OSBPL8, PSME3, RYR1

C5orf46, CTNNB1, LOC283392, OR52K2, SHROOM2

11p15.5 LOH CTNNB1 p. S45F

11p15.5 ROI L

No

066784

None

NRP1, ZNF469

AZU1, C10orf71, DGCR8, DSCAML1, RNASEK

11p15.5 LOI

11p15.5 ROI R + L

Yes

066789

DICER1 M1402_E23 splice region

CTNNB1, FAM120C, GPR27, LOC730755, PP1R13L, RPAP1, SRRSF4, TYRO3, ZNF775

ACTR10, BICD2, C10orf108, C1orf86, C21orf122, DSC2, IDH3G, KCND3, KIAA0125, NBEAL2

11p15.5 LOH

11p15.5 LOH L

No

066792

NYNRIN p.R1592* ASXL1 p.V1297I

DNHD1, MAP3K4, QSOX2, SPERT, TROAP

None

11p15.5 LOI

11p15.5 LOI L

No

069391

None

CRAT, ROS1

NPRL3, ROS1

11p15.5 LOI ROS1 p. Q1889fs

N/A

No

069394

None

SMC1A

EIF1AX, GSPT2, MAP3K4, TRIO, UNC80, VILL

Not shared 11p15.5 LOI – R; 11p15.5 ROI – L

N/A

No

069396

WT1 p.R441*

None

APOB, NBEAL2, PACS2, KCNQ1

11p15.5 LOH

N/A

No

069399

None

SPTBN5

CHST6, CLIP1, DGCR8, MAGI3, RERE, SMC1B

11p15.5 LOI

11p15.5 LOI L

Yes

044978

None

MCPH1, STK10

ATP6V1B2, C9orf131, DOCK9, LCN10, MDN1, PRRC2B, SLC6A20, TP53, ZNF805

11p15.5 LOI

N/A

No

051020

None

HIST1H3I, ZNF664

HEATR3

11p15.5 LOI

N/A

Yes

051024

WT1 p.T305fs

NLGN3, UBE4A, ZFHX2, CTNNB1

FAM199X, DSPP, PPP1R11

11p15.5 LOH

N/A

No

051026

None

ACTB, AMAC1, AP2B1, LDHAL6B, LZTR1, NKX2-1, PRRC2B, SEC14L3, TP53, TTC17

CHD4, EVC, RBMX, CASQ2

11p15.5 LOI

N/A

No

051028

WT1 p.Y337*

GLDN, GPR149, CTNNB1

CCDC61, CTNNB1, FAM159B, SNTG1, ZNF324, AEBP1

11p15.5 LOH

N/A

Yes

018908

None

CRIPAK, TMEM151B

None

11p15.5 LOI

N/A

Yes

043953

CDC73 p.M1T

ANKRD34B, DNAH5, FRG1

None

11p15.5 ROI

N/A

No

051025

None

RYR1, IRS4

None

11p15.5 LOI

N/A

Yes

  1. N/A—sample not available for assessment; 11p15.5 LOI—loss of imprinting (aka ICR1/H19 hypermethylation), 11p15.5 LOH—copy neutral loss of heterozygosity (aka paternal uniparental disomy), 11p15.5 ROI—retention of imprinting (normal physiologic imprinting).
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