Table 2 Shared noncoding variants in paired synchronous bilateral Wilms tumor samples that underwent whole genome sequencing (n = 15)

From: Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q

Case ID

Tumor 1 noncoding somatic variant counts

Tumor 2 noncoding somatic variant counts

Shared noncoding somatic variant counts

11p15.5 Status

Predisposing germline variants

SJWLM066770

136

119

0

LOH

REST

SJWLM066771

54

74

6

LOI

No

SJWLM066773

38

41

0

ROI

TRIM28, BRCA1

SJWLM066776

122

174

5

LOH

WT1

SJWLM066777

69

59

0

ROI

TRIM28

SJWLM066778

379

68

1

LOI

No

SJWLM066779

83

230

0

LOI

BLM

SJWLM066780

97

104

0

LOH

WT1

SJWLM066784

73

83

1

LOI

No

SJWLM066789

125

58

2

LOH

DICER1

SJWLM066792

79

16

1

LOI

ASXL1, NYNRIN

SJWLM069391

102

121

63

LOI

No

SJWLM069394

43

104

1

LOI/ROI

No

SJWLM069396

38

90

2

LOH

WT1

SJWLM069399

136

55

1

LOI

No

  1. LOH loss of heterozygosity, LOI loss of imprinting, ROI retention of imprinting.