Fig. 5: Reconstructed protein interactions between MYC promoter and its enhancers. | Nature Communications

Fig. 5: Reconstructed protein interactions between MYC promoter and its enhancers.

From: The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer

Fig. 5: Reconstructed protein interactions between MYC promoter and its enhancers.The alternative text for this image may have been generated using AI.

DBPs with binding motifs on the promoter region are aligned on the left, while those with binding motifs on the enhancers are aligned on the right. In the middle, proteins that connect DBPs through a shortest path. Each dot represents a protein. Color, size and shape codes are explained in the Tutorial section of the PENGUIN web service at https://penguin.life.bsc.es/. In this figure, only the edges of network paths with PrCa SNPs in enhancer binding motif are represented (orange lines). Such PrCa SNPs are indicated beside the name of the enhancer-bound DBP (e.g. FOXA1-rs10090154); PrCa SNPs in intermediate proteins are indicated with an asterisk (e.g. AR); the proteins found to be enriched in the GWAS+ cluster are highlighted in bold (e.g. PIAS1); druggable proteins from DrugBank are indicated as triangles.

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