Fig. 3: Differential frustration conservation patterns unmask functional constraints in the hemoglobin subunits. | Nature Communications

Fig. 3: Differential frustration conservation patterns unmask functional constraints in the hemoglobin subunits.

From: Local energetic frustration conservation in protein families and superfamilies

Fig. 3

FrustraEvo results based on the SRFI for a ɑ/β-globins, b only ɑ, and c only β. Rectangles denote functionally relevant positions explained in more detail in Supplementary Table 2. In blue asterisks, we marked position 39 in the ɑ/β MSA, which corresponds to a highly frustrated Lys40ɑ but to a neutral Gln39β. The reference structure for this analysis corresponds to the Human Hemoglobin PDB 2DN1. Source data are provided as a Source Data file.

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