Fig. 4: Large-scale application of frustration conservation analysis in coronaviruses.
From: Local energetic frustration conservation in protein families and superfamilies
a Pearson correlation plot showing mean FrustIC vs mean SeqIC per S3Det cluster computed for Coronavirus proteins (see Methods). P value corresponds to a two-sided test. Error bands in the correlation plots correspond to a 95% confidence interval. b Distribution of frustrationally conserved residues (FrustIC > 0.5) for each S3Det cluster containing the corresponding SARS-CoV-2 protein. We considered frustration conservation when FrustIC > 0.5. The proportion of each protein is normalized by its length (Supplemental Table 3). c MSFA showing FrustraEvo results for selected functional domains in PLPro. Cells that are colored correspond to FrustIC > 0.5, while white cells mean that FrustIC ≤ 0.5. Color of the cells represents the median SRFI value computed with FrustratometeR (see methods for frustration states definitions). The amino acid identities correspond to the consensus sequence, and the size of the letter is proportional to SeqIC. Source data are provided as a Source Data file.
