Fig. 3: The cPcdh genes are expressed from H3K9me3/H3K36me3-enriched facultative heterochromatin domains. | Nature Communications

Fig. 3: The cPcdh genes are expressed from H3K9me3/H3K36me3-enriched facultative heterochromatin domains.

From: Outward-oriented sites within clustered CTCF boundaries are key for intra-TAD chromatin interactions and gene regulation

Fig. 3: The cPcdh genes are expressed from H3K9me3/H3K36me3-enriched facultative heterochromatin domains.The alternative text for this image may have been generated using AI.

a H3K9me3 and H3K36me3 ChIP-seq profiles of the three Pcdh clusters in mouse neocortex, showing colocalization of both the active mark of H3K36me3 and inactive mark of H3K9me3. b RNA-seq as well as H3K4me3 and H3K9ac ChIP-seq profiles of the cPcdh clusters in mouse neocortex, showing a strong correlation between each cPcdh gene and the enrichment of active marks. c The H3K9me2 ChIP-seq and MeDIP-seq profiles of the cPcdh clusters, showing enrichments of the repressive mark of H3K9me2 and DNA methylation at most cPcdh genes in the mouse neocortex.

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