Fig. 4: CAP-TAC1 is a potent tachykinin receptor agonist.
From: A class of secreted mammalian peptides with potential to expand cell-cell communication
a Schematic and annotation of the primary amino acid sequence for full-length mouse TAC1 preproprotein and its cleavage products. b Sequence alignment of known tachykinins and CAP-TAC1, with the C-terminal motif highlighted in pink. c–e Chemiluminescent signal intensity in PathHunter beta-arrestin CHO-K1 cells transfected with human TACR1 (c), TACR2 (d), and TACR3 (e) following treatment with the indicated concentration of CAP-TAC1, substance P (6-11), or substance P (SP). f Relative levels of CAP-TAC1, substance P (6-11), or substance P (SP) in mouse plasma following incubation at 37 °C for the indicated time. c–e N = 2 biological replicates per concentration and data shown as means; for (f), N = 2 biological replicates per condition and data shown as means. P value were calculated with two-way ANOVA. Source data are provided as a Source Data file.
