Fig. 3: mCAs detected in paired tumor and peripheral blood leukocytes from one of the two informative BL cases.
From: Mosaic chromosomal alterations in peripheral blood leukocytes of children in sub-Saharan Africa
The figure shows three mCAs > = 2MB in size (chromosome 1q duplication, chromosome 3q deletion, and 6q deletion) detected at cell fraction (CF) ≥ 0.09 in peripheral blood leukocytes and at CF > 0.8 in tumor WGS data from the same BL patient. The mCAs were the same event types detected in similar but not identical genomic regions. a The 3 detected mCAs in WGS tumor data. b The 3 detected mCAs in SNP array data from peripheral blood leukocytes. Upper panels in the figures: Log depth of read coverage of WGS data or exponentiated Log R ratio (eLRR) of SNP data, respectively; Bottom panels in the figures: phase B allele frequency (pBAF) in WGS data or SNP array data, respectively. Gray color indicates regions with a normal state, all other colors (orange, blue, green) indicate regions with mCAs. ‘Source data are provided as a Source Data file’.
