Fig. 5: Molecular mechanism of G-protein selectivity of prostaglandin receptors. | Nature Communications

Fig. 5: Molecular mechanism of G-protein selectivity of prostaglandin receptors.

From: Structures of human prostaglandin F2α receptor reveal the mechanism of ligand and G protein selectivity

Fig. 5: Molecular mechanism of G-protein selectivity of prostaglandin receptors.The alt text for this image may have been generated using AI.

a Sequence alignments of key residues that determines the FP receptor – Gαq coupling specificity. b The TM6 displacement of the FP receptor, EP2 receptor and EP3 receptor when they couple with G protein. FP receptor, EP2 receptor and EP3 receptor are colored blue, green and deep blue respectively. Gαq, Gαs and Gαi are colored orange, red and yellow respectively. c The hydrogen bonds or salt bridge between FP receptor and Gαq (orange). d The potential clash between FP receptor and the α5 helix of Gαs (red) in a FP-Gαs model. e The potential clash between FP receptor and the α5 helix of Gαi (yellow) in a FP-Gαi model.

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