Fig. 6: Rv2067c-H3 peptide complex model. | Nature Communications

Fig. 6: Rv2067c-H3 peptide complex model.

From: The Mycobacterium tuberculosis methyltransferase Rv2067c manipulates host epigenetic programming to promote its own survival

Fig. 6

Rv2067c-H3 peptide complex model (middle panel) depicting H3 peptide (73-EIAQDFKTDLR-83) binding in the substrate-binding trough. The H3 peptide was modeled in two binding modes along the trough, i.e., from N- to C-terminal (left panel) or from C- to N- terminal (right panel) with respect to the active site (broken white circle). In both modes, H3K79 can access the SAM methyl group in a similar fashion seen in MTase-substrate complexes (Supplementary Fig. 9a–h). SAM S-adenosyl-L-methionine. Scale bars 10 Å. The coordinates for the Rv2067c-H3 peptide model are available as Supplementary Data 4.

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