Fig. 3: Rco1 interactions in the Rpd3S complex.
From: Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex
a Overview of Rco1 interactions with Sin3, Rpd3, and Eaf3. Interfaces shown in b-f are highlighted. b Interaction of the Rco1A N-terminus with the Sin3 HID. Interacting residues Rco1A Glu98 and Sin3 Lys896 and Arg897 are shown as sticks. c Rco1A complements the eight-strand β-sheet of Rpd3. d Rco1A SID and PHD1 form a heterodimer with Eaf3A. e Rco1A PHD2 and the linker region of Rco1A are located below Rpd3 and interact with the Sin3 linker, gating loop (HID), and PAH3. f The Rco1B–Eaf3B interface is similar to the Rco1A–Eaf3A heterodimerization interface. Additionally, Rco1A packs against the Rco1B SID and the MRG domain of Eaf3B.
