Fig. 4: The Rpd3S complex forms extensive contacts with the nucleosome.
From: Structure of the complete Saccharomyces cerevisiae Rpd3S-nucleosome complex
a Overview of Sin3, Rco1, and Eaf3 interaction interfaces with nucleosomal, extranucleosomal DNA, H3 and the H2A–H2B acidic patch. Interfaces shown in b-f are highlighted. b Sin3 contacts the phosphate backbone of nucleosomal DNA at SHL 2. c Rco1A interacts with the phosphate backbone of extranucleosomal DNA at SHL 8. d Eaf3A contacts both DNA gyres at SHL 1 and 7.5 and is positioned near extranucleosomal DNA at SHL8. e Eaf3B interacts with nucleosomal DNA similar to EAF3A. f Rco1 interacts via an N-terminal arginine residue with the H2A-H2B acidic patch. Interaction of the arginine residue with H2A residues Glu61, Asp90, and Glu92 are shown as sticks. Heteroatoms are colored canonically.
