Fig. 4: Assessing the role of CNVs in cellular transcriptomic heterogeneity.
From: Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
a Percentage of cell lines whose transcriptomic subclusters are associated or not associated with CNV subclones in all cell lines (left), discrete pattern cell lines (middle), and continuous pattern cell lines (right), respectively. b Representative cell lines with or without the association between transcriptomic subclusters and CNV-based subclones: CNV subclone, identified by chromosomes 2, 5 and 18, is linked to transcriptomic subcluster (upper, HeLa,); CNV subclones, identified by chromosome 13, are not linked to transcriptional subclusters (middle, HT-29); there is only one CNV clone type existing within the cell line (bottom, MDA-MB-453). c The differentially expressed genes between subclusters are enriched in CNV regions for listed cell lines (DEG number: n = 284 in cluster 3 of 786-O, n = 284 in cluster 0 of HeLa, n = 289 in cluster 2 of Hep G2, n = 159 in cluster 1 of HNSCCUM-03T, n = 643 in cluster 2 of Huh7, n = 256 in cluster 1 of MDA-MB-468, n = 638 in cluster 4 of RKO, n = 1351 in cluster 4 of SNB75). A one-tailed hypergeometric test was used to test the statistical significance. Source data are provided in the Source Data file.
