Fig. 2: Photoreceptor synapses are reduced but stable following treatment. | Nature Communications

Fig. 2: Photoreceptor synapses are reduced but stable following treatment.

From: Late gene therapy limits the restoration of retinal function in a mouse model of retinitis pigmentosa

Fig. 2

Histology of rod and cone synapses in cyan (CtBP2) at 7 M from (from left to right) WT, untreated (Cngb1neo/neo;cre-), early, mid and late-treatment timepoints. Nuclei in white (DAPI) and rod ON bipolar cells in red (PCP2) to visualize approximate location of bipolar cell bodies and dendrites. The square region in top row enlarged below. Scale bar: 50 µm. Representative images chosen from two to four biological replicates imaged per cohort.

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