Fig. 4: Structure of Pf20Sβ6A117D with WLW-vs.
a Overall structure of the Pf20Sβ6A117D–WLW-vs complex. The four bound inhibitor molecules are shown in orange spheres, and the β6 A117D mutation sites are highlighted in magenta spheres. b A cut-open view of the EM map of the complex showing the locations of the inhibitors and the β6 A117D mutation. c, d The EM densities of WLW-vs inside the β2 (c) and β5 (d) catalytic pockets. e Alignment of β2 and β5 catalytic pockets shows the altered positions of the inhibitor’s morpholino and indole groups at the two sites.
