Fig. 2: A common cluster of contractile mesenchymal cells encompasses myofibroblasts and pericytes.
From: Distinct mesenchymal cell states mediate prostate cancer progression
a Canonical myogenic and smooth muscle genes characterize c0 (n = 1401 cells) as contractile mesenchymal cells (left panel), but 2 subpopulations: c0.1 (n = 902 cells) and c0.2 (n = 499 cells) can be further subclassified (middle panel). Relative contribution of the different GEMMs and WTs to c0 is shown in the right panel. b UMAP projection of cells from c0 (n = 1401 cells), showing the expression of different myogenic and smooth muscle genes. Acta2, Myl9, Myh11, and Tangl mark myofibroblasts and pericytes, while Rgs5, Mef2c, and Pdgfrb distinguish pericytes (c0.2). The color scale is proportional to the expression levels. c Dot plot showing the expression levels of genes that distinguish myofibroblasts (c0.1) from pericytes (c0.2). The color scale represents the mean gene expression in the cell groups. d The expression levels of regulons that distinguish myofibroblasts (c0.1) from pericytes (c0.2). The color scale represents the mean expression levels. GEMMs: genetically-engineered mouse models; UMAP: Uniform Manifold Approximation and Projection; WT: wild type.
