Table 1 Heritability and shared environment estimates

From: Estimating the heritability of SARS-CoV-2 susceptibility and COVID-19 severity

Category

Trait

Narrow-sense heritability estimate

Shared environment estimate

Families

Quality score

Susceptibility

+PCR

65% (95% CI: 33–80%)

35% (95% CI:15–51%)

1324

0.84

+PCR High Degree Families

57% (95% CI: 37–78%)

34% (95% CI:20–49%)

296

0.86

Reinfection

Insufficient Sample

17

–

Severity

Hospitalization

55% (95% CI: 51–57%)

45% (95% CI:43–49%)

115

0.03

Days Hospitalized

41% (95% CI: 33–57%)

33% (95% CI:24–38%)

158

0.9

+PCR w/ Intubation

Insufficient Sample

26

 

+PCR w/ Death

Insufficient Sample

0

 
  1. Highest quality heritability and shared environment results as determined by the Quality Score and sample size. A high-quality estimate has a Quality Score greater than or equal to 0.8. Poor quality estimates are those with Quality Scores ≤0.2 (see Polubriaginof et al.‘s discussion of POSA)11. No estimate means no phenotypic variance was accounted for. Binary traits were modeled with (default) and without a proband (case) requirement for family inclusion. (See Polubriaginof et al.)11 Narrow-sense heritability estimates and environmental estimates do not necessarily sum to 1, given the unique environment and error term included in the model.
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