Fig. 8: Schematic diagram illustrating the feedback loop formed by Th17 cells, IL-17A, and CXCL16 that promotes Ph+ B-ALL progression. | Nature Communications

Fig. 8: Schematic diagram illustrating the feedback loop formed by Th17 cells, IL-17A, and CXCL16 that promotes Ph+ B-ALL progression.

From: Targeting IL-17A enhances imatinib efficacy in Philadelphia chromosome-positive B-cell acute lymphoblastic leukemia

Fig. 8

The Th17 cell population and IL-17A expression are distinctively increased in Ph+ B-ALL patients, and high expression of IL-17A promotes the progression of Ph+ B-ALL. IL-17A promotes the proliferation and survival of Ph+ B-ALL cells by activating the BCR-ABL and IL6/JAK/STAT3 signaling pathways. Moreover, IL-17A can increase the secretion of the chemokine CXCL16 from leukemia cells by activating NF-kB, which in turn mediates the differentiation and recruitment of Th17 cells to the leukemia niche microenvironment. Targeting IL-17A or CXCL16 in the leukemia niche microenvironment attenuates the progression of Ph+ B-ALL.

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