Fig. 3: ARGs overlapping by the adult and infant gut accounted for the vast majority of ARG abundance in each cohort. | Nature Communications

Fig. 3: ARGs overlapping by the adult and infant gut accounted for the vast majority of ARG abundance in each cohort.

From: Differential responses of the gut microbiome and resistome to antibiotic exposures in infants and adults

Fig. 3

Analyses of the unique and overlapping (a) ARG-carrying bacterial species, (b) ARGs, (c) drug classes targeted by ARGs, (d) MDR ARGs, (e) mobile ARGs, (f) and drug classes targeted by mobile ARGs in both gut, with respect to the number of individual species/genes/drug classes (top panel) and their relative abundance in the total population of ARGs (bottom panel). “Unique” represents species/ARGs/drug classes that were only present in adult or infant gut regardless of prevalence and abundance. “Unclassified” represents ARGs with unknown bacterial origin, as these ARG-carrying contigs were not detected within the bins. Mean abundance of the 10 most commonly targeted drug classes by ARGs (g) and by mobile ARGs (h) in the adult and infant gut. P-value from the Wilcoxon test with Bonferroni adjustment and red indicates P < 0.05 (significant difference). Seven of the 10 mobile drug classes were shared between cohorts. All P-values were derived from two-sided tests.

Back to article page