Table 4 Summary of non-surgical adverse events
Adverse events | CA-SAP group (n = 51) | SAP group (n = 53) | ||
|---|---|---|---|---|
Grade 1–2 | Grade 3–4 | Grade 1–2 | Grade 3–4 | |
Hematologic | ||||
Neutropenia | 21 (41.2) | 5 (9.8) | 27 (50.9) | 3 (5.7) |
Leukopenia | 30 (58.9) | 7 (13.7) | 35 (66.0) | 4 (7.5) |
Thrombocytopenia | 7 (13.7) | 1 (2.0) | 0 (0.0) | 2 (3.8) |
Anemia | 15 (29.4) | 1 (2.0) | 21 (39.6) | 0 (0.0) |
Gastrointestinal | ||||
Nausea | 19 (37.3) | 0 (0.0) | 23 (43.4) | 0 (0.0) |
Vomiting | 11 (21.6) | 0 (0.0) | 13 (24.5) | 0 (0.0) |
Anorexia | 10 (19.6) | 0 (0.0) | 11 (20.8) | 1 (1.9) |
Diarrhea | 14 (27.5) | 2 (3.9) | 8 (15.1) | 2 (3.8) |
Bleeding | 8 (15.7) | 1 (2.0) | 8 (15.1) | 1 (1.9) |
Liver | ||||
AST elevation | 11 (21.6) | 3 (5.9) | 8 (15.1) | 3 (5.7) |
ALT elevation | 9 (17.6) | 5 (9.8) | 10 (18.9) | 3 (5.7) |
Bilirubin increased | 8 (15.7) | 0 (0.0) | 8 (15.1) | 0 (0.0) |
Cardio-renal | ||||
Hypertension | 10 (19.6) | 0 (0.0) | 2 (3.8) | 0 (0.0) |
Proteinuria | 8 (15.7) | 0 (0.0) | 1 (1.9) | 0 (0.0) |
Respiratory | ||||
Immune pneumonitis | 2 (3.9) | 0 (0.0) | 0 (0.0) | 0 (0.0) |
Dermatologic | ||||
Rash | 9 (17.6) | 0 (0.0) | 5 (9.4) | 0 (0.0) |
Hand–foot syndrome | 8 (15.7) | 0 (0.0) | 1 (1.9) | 0 (0.0) |
Systemic | ||||
Fatigue | 15 (29.4) | 1 (2.0) | 19 (35.8) | 1 (1.9) |
Fever | 10 (19.6) | 0 (0.0) | 5 (9.4) | 0 (0.0) |
Others | ||||
Peripheral sensory neuropathy | 6 (11.8) | 0 (0.0) | 7 (13.2) | 1 (1.9) |
Hypothyroidism | 7 (13.7) | 0 (0.0) | 1 (1.9) | 0 (0.0) |
Stomatitis | 9 (17.6) | 1 (2.0) | 4 (7.5) | 0 (0.0) |
