Fig. 1: Challenges in ssEM alignment.
From: Petascale pipeline for precise alignment of images from serial section electron microscopy
a Mechanics of discontinuous defect creation. Discontinuous defects cause tissue loss and make neighboring areas particularly challenging to align. b Example of a crack (white line). c Example of a fold (black line). d Examples of other artifacts: knife chatter (top left), grid pattern (top right), dust (bottom left), brightness variation (bottom right).
