Fig. 2: Trans-ancestral TL GWAS and PRS analysis.
From: Unraveling the causal genes and transcriptomic determinants of human telomere length
A Manhattan plot of various TL GWASs and GWAS meta-analysis. The x-axis represents the genome in physical order; the y-axis shows -log10 two-sided P-values for all variants using an inverse-variance weighted fixed effects model and a total sample size n = 644,553. B The quantile-quantile (Q-Q) plot compared the two-sided P-values generated from this fitted distribution against the observed P values. C LocusZoom plot for regional associations of a locus associating with TL in SWT1 gene, SNPs are colored according to their LD with the lead SNP, rs10798002. The left y-axis shows association -log10 two-sided P-values for all SNPs in this locus, the right y-axis shows the recombination rate and the x-axis shows the chromosomal position. The bottom of plot shows the near genes. D Dot plot of GO enrichment for the nearest genes of TL-associated variants. The diameter indicates the number of genes overlapping the gene ontology term and the color indicates the BH-adjusted enrichment P value. E Scatter plot for RTL vs. PRSs with a simple linear regression line fitted in this study (n = 166) and GTEx (n = 442). The grey shade area represents 95% confidence interval.
