Fig. 3: Alternative splicing as a potential Sox9-regulated mechanism in the beta cell.
From: Sox9 regulates alternative splicing and pancreatic beta cell function
A Transcript-level alignment of mapped reads from RNA-seq data reveals genes dysregulated at the isoform level in the Ins-Cre;Sox9-/- islets. A volcano plot of the distribution of genes is shown. Red highlights the 315 genes with a q value < 0.05. B The top genes significantly alternatively spliced in Sox9-knockout samples are listed. C Gene ontology and KEGG pathway analysis of genes that are significantly alternatively spliced. D rMATs analysis of the five main alternative splicing events in the differentially expressed genes from A. E Abundance of Srsf5 at the gene level in control and Ins-Cre;Sox9-/- islets. Source data are provided as a Source Data file.
