Fig. 4: Molecular model of LMP1 in complex with TRAF6.

a In silico structure of the LMP1 peptide G₃₇₈PVQLSY₃₈₄ (green) bound to the receptor-binding interface of the TRAF domain of TRAF6 (blue), as derived from a RANK-TRAF6 crystal structure (PDB 1LB5)⁴⁶. Hydrogen bonds formed between LMP1 and TRAF6 are indicated by yellow, dashed lines. b TRAF6 environment around position P₀ of LMP1 (in silico model; green), compared to RANK (PDB 1LB5; yellow) and CD40 (PDB 1LB6; salmon). c TRAF6 environment around positions P₁-P₃ of LMP1 compared to RANK and CD40. The tyrosine at P₃ of RANK and LMP1 adopts a stretched conformation versus the kinked conformation of F₂₃₈ of CD40. Note that the mutation N₂₃₇D was introduced into CD40 to enable crystallization⁴⁶.