Fig. 2: Comparison of Progressors and Non-Progressors to identify a COVID-19 prognostic signature. | Nature Communications

Fig. 2: Comparison of Progressors and Non-Progressors to identify a COVID-19 prognostic signature.

From: Longitudinal single cell atlas identifies complex temporal relationship between type I interferon response and COVID-19 severity

Fig. 2: Comparison of Progressors and Non-Progressors to identify a COVID-19 prognostic signature.

UMAP representations show the cell-state enrichment fold-change between Mild1 progressors and non-progressors in T, NK cells (A), B cells (B), and myeloid cells (C). Yellow: cell states (gene expression neighborhoods) enriched in Progressors. Magenta: cell states depleted in Progressors. Red bar plots: enriched Gene Ontology (GO) terms associated with the union across all cell subtypes of genes upregulated in Progressors. Heatmaps on the right: pseudobulk expression levels of type I IFN genes upregulated in Progressors. Source data are provided as a Source Data file.

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