Fig. 5: MarsGT identifies MAIT-like rare cell populations and eGRNs in multi-sample melanoma scRNA-seq and scATAC-seq.
From: MarsGT: Multi-omics analysis for rare population inference using single-cell graph transformer
a UMAP visualizes MarsGT’s predicted cell cluster results, annotated based on marker genes. b Dotplot depicts the expression value and proportion of marker genes within the cell clusters predicted by MarsGT. c UMAPS showcases the marker genes of MAIT cells. d Showcasing the marker genes of MAIT cells. Each box showcases the minimum, first quartile, median, third quartile, and maximum gene signature enrichment scores on different MAIT-like cell populations (MAIT-like 1: \(n\) = 1071, MAIT-like 2: \(n\) = 67). The \(p\)-value is calculated by the Mann-Whitney U test with two-sided. e The upset plot illustrates the peaks present in CD8 + T cell subpopulations. f The upset plot demonstrates the genes found in CD8 + T cell subpopulations. g Pathway enrichment across different MAIT-like cell populations. Colors represent distinct cell populations, while the size of the dots indicates the ratio of enriched genes. \({p}\)-values were calculated based on one-sided hypergeometric test. Multiple testing correction was performed by using FDR-adjusted \(p\)-values. h The expression and accessibility of ZBTB16-regulated genes across various MAIT cell populations. i The regulatory relations of ZBTB16 in different MAIT-like cell populations. Green means the common regulatory relations between MAIT-like 1 and MAIT-like 2. Light blue means the regulatory relations unique in MAIT-like 1. Dark blue means the regulatory relations unique in MAIT-like 2. Source data are provided as a Source Data file.
