Fig. 6: MarsGT reveals the good prognosis with high IFN-I response impairs MAIT cell responses by increasing IL10 and inducing IL15 and IL12 from DC.
From: MarsGT: Multi-omics analysis for rare population inference using single-cell graph transformer
a The number of cells in MAIT-like cell populations in different melanoma patients. b The number of cells in MAIT cells and DC cells in high IRC and low IRC. c Expression of ISGs in MAIT cells across different IRC. d Enrichment score of MAIT effective gene signature and exhausted gene signature across varying IRC. Each box showcases the minimum, first quartile, median, third quartile, and maximum gene signature enrichment scores in different IRC in MAIT cells (High IRC: \(n\) = 176, Low IRC: \(n\) = 895). The \(p\)-value is calculated by the two-sided Mann-Whitney U test. e Expression of critical cytokine genes in DC cells across varying IRC. f Expression of IFN-I receptor coding genes in MAIT cells across different IRC. g Expression of secreted factors coding genes in MAIT cells across different IRC. h The mechanism of MAIT-like cells with different IRC samples. i The regulatory mechanism of IFN-II, GzmB, and Perforin in high IRC and low IRC. Green means the common regulatory relations between high IRC and low IRC. Dark blue means the regulatory relations are unique in low IRC. Figure created with BioRender.com. Source data are provided as a Source Data file.
