Fig. 4: βSENP1-KO mice develop glucose intolerance following 2-day HFD.
From: A role and mechanism for redox sensing by SENP1 in β-cell responses to high fat feeding
A, B IPGTT of male pSENP1-KO and pSENP1-WT mice fed with CD (n = 9, 8 mice) and 2-HFD (n = 10, 11 mice, *p = 0.023, 0.027). C, D OGTT of male pSENP1-KO and pSENP1-WT mice fed with CD (n = 6, 6 mice) and 2-HFD (n = 10, 8 mice, *p = 0.019, **p = 0.0017). E, F Exocytosis from β-cells of βSENP1-WT and βSENP1-KO mice after 2-day (n = 34, 32, 24, 34, 56, 56, 18, 21 cells, @@p = 0.0017, 0.0018, 0.0032, 0.0030; from 4, 3, 6, 2 mice, *p = 0.020, **p = 0.0029, 0.0036, 0.0092, 0.0097) and 4-week HFD (n = 46, 45, 32, 31, 48, 56, 68, 63 cells, @p = 0.031, 0.021, @@p = 0.0011, 0.0017, 0.0044; from 4, 3, 4, 6 mice, *p = 0.027, 0.044). G, H IPGTT of male βSENP1-KO and βSENP1-WT mice fed with CD (n = 6, 5 mice) and 2-day HFD (n = 10, 12 mice, *p = 0.044, 0.025). I Plasma insulin levels during IPGTT after CD or 2-day HFD (n = 8, 8 mice, **p = 0.0049). J, K OGTT of male βSENP1-KO and βSENP1-WT mice fed with CD (n = 4, 4 mice) and 4-week HFD (n = 13, 11 mice, *p = 0.021, 0.040, 0.050, 0.023). L Plasma insulin levels during OGTT after CD or 4-week HFD (n = 8, 8 mice, *p = 0.017). In panels E and F data are shown as individual cells (gray) or cells averaged by animal (dark). Data are mean ± SEM, compared with student two-sided unpaired Student’s t test (AUCs) or two-way ANOVA followed either by Bonferroni (two-sided; panels A–D, G–L) or Tukey (two-sided; panels E, F) post-test. Source data are provided as a Source Data file.
