Fig. 4: Structural similarity to aminergic neurotransmitter receptors.
From: Molecular basis of human trace amine-associated receptor 1 activation
A Phylogenetic analysis of the structurally conserved residues of human aminergic receptors using the GPCRdb tool (Top). hTA1 is circled for orientation. Sequence similarity and identity calculated for complete receptor sequences or only structurally conserved positions (bottom). B Structural comparison of the hTA1-Gs and 5-HT4R-Gs (PDB: 7XT8) complexes and superposition of the receptors shown from different angles. Light blue, hTA1; dark blue, 5-HT4R; Ro5256390, magenta; orange, serotonin; Gαs, green; Gβ1, salmon; Gγ2, purple.
