Fig. 4: Cross-microbial clade functional associations with NHA and human hosts.
From: Functional host-specific adaptation of the intestinal microbiome in hominids
a KO terms consistently enriched in human- (blue diamonds) and NHA-associated (orange diamonds) taxonomic clades. Individual genus-level PFisher -values are shown in points colored by phylum. Shown P-values are unadjusted for taxon-level tests and Bonferroni-corrected for multiple testing for the meta-analysis. All tests were two-sided. b Prevalence patterns of KO terms in human- (blue) and NHA-associated (orange) Prevotella SGBs. Filled shapes represent KOs with significant (Q < 0.05, Fisher’s exact test, two-sided) differences in the statistical test. c Results of the tree reconciliation analysis for the cydA gene in Prevotella SGBs found in humans (blue) and NHAs (Pan: orange; Gorilla: green) demonstrate a history of frequent transfer events across 1000 reconciliations with random seeds. Filled and empty shapes represent cydA-positive and -negative SGBs, respectively. Red arrows depict gene transfer events from a donor to a recipient node found in at least 50% of reconciliations and are weighted by frequency. Red triangles mark nodes that were identified as gene transfer recipients with >50% frequency independent of the donor node. Black circles mark speciation events with >50% frequency. The ten highest abundant Prevotella species with established names are shown for orientation. The Prevotella tree was rooted using Paraprevotella clara as the outgroup (not shown).
