Table 1 Baseline clinical characteristics and follow-up events for participants included in each analysis set: ARIC mid-life baseline (Visit 3), ARIC late-life baseline (Visit 5), and HUNT

From: Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development

 

ARIC Visit 3 (1993-1995)

ARIC Visit 5 (2011-2013)

HUNT (2006–2008)

N

10,638

4483

3262

Age (years)

60 ± 6

75 ± 5

65 ± 10

Black race

2201 (20%)

763 (17%)

0

Male

4886 (46%)

1861 (42%)

1975 (61%)

Hypertension

4839 (45%)

3622 (81%)

1352 (41%)

Smoking

6279 (59%)

2593 (58%)

2145 (66%)

Diabetes

1936 (18%)

1560 (35%)

307 (9%)

BMI (kg/m2)

28 ± 5

28 ± 5

28 ± 4

eGFR (ml/min/1.73 m2)

86 ± 15

72 ± 17

88 ± 16

Coronary disease

673 (6%)

662 (15%)

566 (17%)

Atrial fibrillation

112 (1%)

232 (5%)

208 (6%)

Incident HF events

822

408

340

F/U Time (Years)

10.0 [10.0, 10.0]

7.2 [5.6, 7.8]

10.0 [9.2, 10.6]

Event Rate

0.8 [0.8, 0.9]

1.4 [1.3, 1.5]

1.2 [1.1,1.3]

  1. Incident HF events post-ARIC Visit 3 and post-ARIC Visit 5 were not overlapping. Continuous variables are provided as n ± standard deviation or n [25th percentile limit, 75th percentile limit] as appropriate.
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