Table 1 Pharmacokinetic parameters in mouse for SJ3149 obtained after intravenous (IV), oral (PO), and intraperitoneal (IP) administration

From: Selective CK1α degraders exert antiproliferative activity against a broad range of human cancer cell lines

Route

Dose (mg/kg)

Tmax (hr)

C0/Cmax (ng/mL)a

AUClast (h*ng/mL)

T1/2 (h)

CL (mL/min/kg)

Vss (L/kg)

%F

IV

3

NA

4510.70

1374.61

0.77

36.24

0.67

NA

PO

50

0.25

4740.05

2848.12

2.57

–

–

12

IP

50

0.25

6683.49

16,983.57

3.08

–

–

74

  1. NA not applicable.
  2. aBack extrapolated concentration at time zero in the IV group.
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