Fig. 1: Miami-Plot of variants associated with eGFR and UA.
Results of the cross-ancestry X chromosome-wide association analysis for eGFR (positive panel) and UA (negative panel). Chromosomal position and cytobands of genome-wide significant associations are indicated on the X-axis. The y-axis reports the (negative) log10(p-values) of associations (β coefficient of additive genetic effect in linear regression analysis, two-sided). Values in [−1.3,1.3] are not displayed. Color coding indicate the strata where the smallest P-value was observed: overall = gray; male = blue; female = red; and black = not genome-wide significant. Horizontal dashed lines represent the genome-wide significance threshold (α = 5 × 10−8), correcting for multiple testing. Each locus is characterized by candidate gene name, novelty and sex interaction. Bold italics gene names indicate loci with sex interactions and are again color-coded according to the sex with the higher genetic effect size. Novel loci are marked by a box.
