Fig. 1: Schematic of NIR-II brain-target theranostic system for dual-target therapy of AD via a four-step route.
From: A one-two punch targeting reactive oxygen species and fibril for rescuing Alzheimer’s disease
(i) The co-assembly of nanodrug (Ang-AIE NCs, termed Ang-NCs). (ii) the NIR-II imaging monitored the BBB-traversing process of Ang-NCs. (iii) the inflammation-associated reactive oxygen species (ROS) environment stimulated the controllable release of Ang-NCs. iv) the activation of the self-enhanced dual-targeting program: compound 3 specifically inhibits the formation of amyloid-beta (Aβ) fibrils, degrades toxic fibrils, and inhibits reaggregation. Compound 6 relieves harmful inflammation-associated ROS and promotes the inhibition of Aβ fibrils generation.
