Fig. 2: Reaction design and discovery.

a Our design: construction of central chirality followed by central-to-axial chirality conversion. b Beyond design: synergistic construction of central and axial chirality via a single stereodetermining steps.

a Our design: construction of central chirality followed by central-to-axial chirality conversion. b Beyond design: synergistic construction of central and axial chirality via a single stereodetermining steps.