Fig. 2: Host factors associated with SARS-CoV-2 virions interact with each other and with viral RNA and structural proteins within infected cells.
From: Proteomic analysis of SARS-CoV-2 particles unveils a key role of G3BP proteins in viral assembly
a Protein-Protein interaction network of host factors associated with virions produced from A549-ACE2 and Calu-3 cells was built based on curated interactions in STRING. The nodes represent identified host proteins associated with virions from A549-ACE2 cells (ellipses) and Calu-3 cells (diamonds) or both (polygons) and the edges represent known cellular interactions between two proteins of the network. Proteins without connection are shown on the left. Proteins were sorted according to their cellular and molecular functions and are highlighted in different colors accordingly. Detailed KEGG and GO term analyses are provided in Supplementary Fig. 2a. b Protein-protein interaction network of virion-associated factors with SARS-CoV-2 structural proteins was built based on known interactions within infected cells (BIOGRID-PROJECT-covid19). Edges represent direct interactions of cellular proteins with one of the viral structural proteins, N (purple), M (red), S (blue) and E (orange). Proteins in cyan were previously shown to interact with SARS-CoV-2 RNA in the cells29,30,31,32,33,54. Protein in grey are RNA binding proteins (RBP) (according to RBPase v0.2.1 alpha).
