Table 1 Cytochrome P450 (CYP) pharmacogene variation in American Indian and Alaska Native peoples

From: Implementing community-engaged pharmacogenomics in Indigenous communities

 

CYP genes

 

AIAN tribe or geographic region

CYP2A6

CYP2B6

CYP2C9

CYP2C19

CYP2D6

CYP3A4

CYP3A5

CYP4F2

CYP4F11

Confederated Salish and Kootenai Tribes in Montana

—

—

●16

—

●16

●16

●16

—

—

Oglala Sioux Tribe in South Dakota

—

—

—

●42

—

—

—

—

—

Yup’ik people in Yukon-Kuskokwim Delta, Alaska

●43

●43

● 17

—

—

●21

●21

●17

●17

Northern Plains Tribe in South Dakota

●19

—

—

—

—

—

—

—

—

Southcentral Foundation in Alaska

●18

●18

—

—

—

●21

●21

●17

●17

Southwest Tribe in Arizona

●44

—

—

—

—

—

—

—

—

  1. The table was modified and updated (two additional citations18,21) from Henderson et al. 45, and includes studies that involved specific AIAN tribes and geographic regions in the United States. Studies that reported more generalized population descriptors (broad AIAN groups), non-AIAN Indigenous groups, and ancestry-informed and imputed alleles were excluded from this table. The systematic literature review inclusion criteria from Henderson et al. 45 was followed for the additionally included publications. ● indicates that pharmacogenomics data from those tribes/regions has been published and references are indicated in the superscript.—indicates that no data is available.
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