Fig. 1: α-C−H functionalization of alkyl amines with electrophiles.
From: Asymmetric α-C(sp3)−H allylic alkylation of primary alkylamines by synergistic Ir/ketone catalysis
a N- versus α-C−H allylic alkylation. b Allylic alkylation of alkyl amines through protecting group strategy. c α-C−H Functionalization of activated primary amines through carbonyl catalysis. d This work: asymmetric α-C−H allylic alkylation of primary alkyl amines by synergistic Iridium/ketone catalysis. M metal, L ligand, E+ electrophile, cat. catalyst, Me methyl, DBU 1,8-diazabicyclo[5.4.0]undec-7-ene, DFO 1,8-diazafluoren-9-one, THF tetrahydrofuran, ee enantiomeric excess, dr diastereomeric ratio, r.t. room temperature.
