Fig. 2: Strong impact of mRNA-1273 vaccination on antibody response overtime.

Antibody levels A, binding to FcγR B, and function C against Spike WT was analyzed in children at different timepoints: before vaccination (V0, n = 14), 1 month (V1, n = 13) after the first dose of mRNA-1273 vaccine, 2 months (V2, n = 9) after the first dose of mRNA-1273 vaccine, 6 months (V6, n = 8) after the first mRNA-1273 vaccine series, as well as 1 month after boosting (post-boost, n = 3). Connecting lines represent identical individuals that were followed over time, and statistical differences were calculated between 2 consecutive timepoints. Non-parametric, two-sided Wilcoxon signed rank test was used to calculate differences between timepoints for paired data, followed by Benjamini-Hochberg correction for multiple testing. P values that are <0.05 are indicated on the graphs. ADCP antibody-dependent cellular phagocytosis, ADNP antibody-dependent neutrophil phagocytosis, ADCD antibody-dependent complement deposition. Source data are provided as a Source Data file.