Fig. 8: Eosinophils and eosinophil cationic protein levels are correlated with bone mass in humans. | Nature Communications

Fig. 8: Eosinophils and eosinophil cationic protein levels are correlated with bone mass in humans.

From: Eosinophils preserve bone homeostasis by inhibiting excessive osteoclast formation and activity via eosinophil peroxidase

Fig. 8: Eosinophils and eosinophil cationic protein levels are correlated with bone mass in humans.

a Representative images of immunofluorescence microscopy of synovial tissue from rheumatoid arthritis (RA) patients. Polynucleated osteoclasts are stained with CD68 (green), eosinophils with EPX (red), and nuclei are visualized by DAPI (blue). Scale bar, 50 µm. Localization of eosinophils near osteoclasts in synovial tissue was detected independently in sections from 5 RA patients. b Correlation between the gene expression of eosinophil gene RNASE2 with osteoclast-related genes NFATC1 and ACP5 in the blood of RA patients (n = 34). c, d Correlation of blood eosinophil counts with trabecular (c), and cortical (d) volumetric bone mineral density (vBMD) in RA patients without glucocorticoids (RA w/o GLC), with glucocorticoids (RA with GLC), and healthy controls (HC) (n = 25). e, f Correlation of serum eosinophil cationic protein (ECP) levels with trabecular (e), and cortical (f) vBMD in RA w/o GLC, RA with GLC, and HC (n = 25). Symbols represent individual participants. P values are based on one-tailed Spearman’s correlation coefficients (8b, 8c, 8e). Asterisks mark statistically significant difference (*P < 0.05, **P < 0.01). Source data are provided as a Source data file.

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