Fig. 2: SNP influences expression of Wnt4 in the uterus. | Nature Communications

Fig. 2: SNP influences expression of Wnt4 in the uterus.

From: A common allele increases endometrial Wnt4 expression, with antagonistic implications for pregnancy, reproductive cancers, and endometriosis

Fig. 2

A Both independently generated knock-in (KI) lines had significantly higher uterine expression levels of Wnt4 in the proestrus phase (KI-1: p = 0.003, KI-2: p = 0.006) and estrus phase (KI-1: p = 0.003, KI-2: p = 0.0025) of the ovarian cycle compared to the wildtype (WT). In all cases, significance was evaluated by Wilcoxon-Mann-Whitney rank sum test. Number of independent samples (i.e. individuals) used for Wnt4 measurements: proestrus: 7 WT, 15 KI-1, 4 KI-2; estrus: 7 WT, 12 KI-1, 5 KI-2. B Expression of other adjacent genes to the SNP such as Cdc42 did not differ between genotypes (p > 0.3). Number of independent samples (i.e. individuals) used for measurements of Cdc42: proestrus: 4 WT, 11 KI-1, 3 KI-2; estrus: 2 WT, 6 KI-1, 4 KI-2. Statistical significance was evaluated by the Wilcoxon-Mann-Whitney rank sum test. Boxplots show the median (central line) and interquartile range (50% of the data fall within the box), with the whiskers covering the range of data (Q1 or Q3 + 1.5IQR).

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