Fig. 4: Overview of catalytic cycle, origin of enantioselectivity and mechanistic insights. | Nature Communications

Fig. 4: Overview of catalytic cycle, origin of enantioselectivity and mechanistic insights.

From: Desymmetric homologating annulation to access chiral pentafulvenes and their application in bioimaging

Fig. 4

A Proposed reaction pathway. B The proposed transition TS-1 depicts the favorable interactions between the aromatic CH of benzyl group and one of the CF3 of the catalyst. The TS-II suggests no such favorable interactions responsible for the origin of enantioselectivity. C Reaction progress monitoring through 1H NMR.

Back to article page