Fig. 6: Effect of therapeutic intervention on severe disease outcomes. | Nature Communications

Fig. 6: Effect of therapeutic intervention on severe disease outcomes.

From: Therapeutic mitigation of measles-like immune amnesia and exacerbated disease after prior respiratory virus infections in ferrets

Fig. 6: Effect of therapeutic intervention on severe disease outcomes.The alternative text for this image may have been generated using AI.

a Study schematic. b–f PBMC-associated viremia titers (b), survival (c), lymphocyte counts (d), and RABV (e) and IAV H1N1 (f) nAb titers of consecutively infected and GHP-88309-treated ferrets from (a). Green shading in (d) denotes normal range. g pdmCA09 nasal lavage titers after IAV challenge of ferrets recovered from CDV disease. h IAV H1N1 nAb titers after challenge of ferrets recovered from CDV disease with pdmCA09 on study day 65. i MRI slices of consecutively infected and GHP-88309-treated (top row), CDV-vaccinated (middle row), or vehicle-treated (bottom row) ferrets, taken 15 dpi with CDV. Axial, coronal, and sagittal slices of the same lung are shown. Arrow heads denote hemorrhagic infiltrates. j 3D MRI reconstructions and segmentations of lungs from consecutively IAV CDV-infected and GHP-88309 or vehicle-treated ferrets. Images were collected 15 dpi with CDV; fluids shown in red. k Lung histopathology of consecutively infected and GHP-88309-treated or uninfected (mock) ferrets, assessed 19 dpi with CDV; scale bars represent 100 μm. Symbols (b, d–h) represent geometric means ± geometric SD, lines intersect means; error was not calculated for later timepoints of the GHP-88309 (+10d) and GHP-88309 (+14d) conditions, when individual animals had reached endpoints and subgroup sizes were below 3. Log-rank (Mantel-Cox) test (c), median survival is stated; 2-way ANOVA with Dunnett’s post-hoc test (e–g); n numbers as specified. Source data are provided as a Source Data file.

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