Fig. 1: Analysis of Sequences of Sarbecovirus RBD and S Proteins. | Nature Communications

Fig. 1: Analysis of Sequences of Sarbecovirus RBD and S Proteins.

From: Broad protection against clade 1 sarbecoviruses after a single immunization with cocktail spike-protein-nanoparticle vaccine

Fig. 1

a Amino acid phylogenetic tree of Sarbecovirus RBDs. Scale bar represents the number of mutation events per residue. Node shapes denote receptor usage (★: ACE2-utilizing, hACE2-capable; ●: ACE2-utilizing, nonhuman ACE2 only; ○: ACE2 non-utilizing), with hACE2-capable referring to viruses able to infect cells expressing human ACE2 in vitro. Clade assignments are indicated by branch and node color (Clade 1A: dark green; Clade 1B: dark red; Clade 2: yellow; Clade 3: light blue; Clade 4: purple). Accession numbers are provided in Supplementary Table 2. b Amino acid phylogenetic tree of Sarbecovirus RBDs in Clades 1A and 1B. Node shapes and branch colors are the same as in Fig. 1a. c Sequence identity of S proteins selected for immunization. White indicates 100% sequence identity, and darker shades of green indicate lower percentages. d Location of amino acid changes of selected S proteins compared to SARS-CoV-2 614D. Gray areas indicate different domains of the S protein, and blue bars indicate amino acid changes in relation to 614D. SP signal peptide, NTD N-terminal domain, RBD receptor binding domain.

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