Fig. 5: Heat shock A-body targeting is regulated by distinct structural pockets.
From: Protein thermal sensing regulates physiological amyloid aggregation
a Cartoon of the pockets surrounding amino acids F184 (red, top), C223 (blue, middle) and T114/I106/N188/V167 (orange, bottom) in the predicted DDX39A structure. Surrounding residues are shown in pink (top), cyan (middle) and yellow (bottom), while the control residues outside of pockets are indicated in green. b MCF-7 cells expressing the indicated DDX39A mutants were subjected to heat shock conditions and quantified for A-body targeting. 10 cells were analyzed per replicate, and values represent means ± s.e.m (n  =  3 independent experiments, a two-tailed Student’s t test was used: *p  ≤  0.05). Source data for all graphs are provided with this paper.
