Fig. 6: Elevated temperature enhances the dynamic properties of the thermo-sensitive A-body constituent DDX39A.
From: Protein thermal sensing regulates physiological amyloid aggregation
a Violin plots of root mean square deviation (RMSD) values from 42620 data points across each 1.6 microsecond simulation at 37 °C and 43 °C for the N-terminus (amino acids 46-250) of DDX39A and DDX39B. The dashed horizontal lines in the violin plot represent the mean. b RMSD of the N-terminal domain of DDX39A (red) and DDX39B (blue) at 37 °C and 43 °C across a 1.6 microsecond molecular dynamics simulation. c The difference in root mean square fluctuations (RMSF) for DDX39A and DDX39B at 43 °C is presented for each residue of the ordered regions of the DDX39 N-terminal domains. d RMSF values were converted to hexadecimal color values (red = increased ΔRMSF) and depicted on the DDX39A N-terminal structure. Source data are provided with this paper.
