Fig. 8: Model depicting the thermo-sensing mechanism of A-body constituents.
From: Protein thermal sensing regulates physiological amyloid aggregation
Amyloid bodies form in response to elevated temperatures. Under heat shock conditions, thermo-sensitive proteins locally denature to expose targeting motifs that interact with the seeding IGS RNA (intergenic spacer noncoding RNA) and mediate amyloid fibril formation. Conversely, thermo-stable proteins maintain their native conformation at high temperatures, masking their targeting motifs, and preventing protein aggregation.
